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Cdc number of deaths from covid vaccine12/2/2023 ![]() However, many existing studies are limited in geographic representation, restricted to cases early in the outbreak, or focused on a limited number of preselected conditions and/or severe outcomes (3–5). Several underlying medical conditions among adults, including diabetes, obesity, chronic kidney disease (CKD), hypertension, and immunosuppression, have been reported to be associated with increased risk for severe illness from COVID-19 (2-4). Careful evaluation and management of underlying conditions among patients with COVID-19 can help stratify risk for severe illness.Īs the COVID-19 pandemic continues, a need remains to understand indicators for severe illness, defined as admission to an intensive care unit (ICU) or stepdown unit, invasive mechanical ventilation (IMV), or death (1). Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, and anxiety disorders were the strongest risk factors for severe COVID-19 illness. The strongest risk factors for death were obesity (adjusted risk ratio = 1.30 95% CI, 1.27–1.33), anxiety and fear-related disorders (aRR = 1.28 95% CI, 1.25–1.31), and diabetes with complication (aRR = 1.26 95% CI, 1.24–1.28), as well as the total number of conditions, with aRRs of death ranging from 1.53 (95% CI, 1.41–1.67) for patients with 1 condition to 3.82 (95% CI, 3.45–4.23) for patients with more than 10 conditions (compared with patients with no conditions).Ĭertain underlying conditions and the number of conditions were associated with severe COVID-19 illness. Essential hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%) were the most common. We used multivariable generalized linear models to estimate adjusted risk of intensive care unit admission, invasive mechanical ventilation, and death associated with frequent conditions and total number of conditions.Īmong 4,899,447 hospitalized adults in PHD-SR, 540,667 (11.0%) were patients with COVID-19, of whom 94.9% had at least 1 underlying medical condition. We used data from more than 800 US hospitals in the Premier Healthcare Database Special COVID-19 Release (PHD-SR) to describe hospitalized patients aged 18 years or older with COVID-19 from March 2020 through March 2021. This study identified frequent underlying conditions and their attributable risk of severe COVID-19 illness. Severe COVID-19 illness in adults has been linked to underlying medical conditions. ![]() Preventing COVID-19 in populations with these underlying conditions and multiple conditions should remain a public health priority, with targeted mitigation efforts and ensuring high uptake of vaccine, when available, in these individuals and their close contacts. What are the implications for public health practice? ![]() Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, anxiety disorders, and the total number of conditions were the strongest risk factors for severe COVID-19 illness. In this cross-sectional study of 540,667 adult hospitalized patients with COVID-19, 94.9% had at least 1 underlying medical condition.
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